CV & Publications

(last update: April 2024)

Vincenzo G. Fiore, PhD, Assistant professor

Contacts:

vincenzo.fiore@mssm.edu
Centre for Computational Psychiatry
Icahn School of Medicine at Mount Sinai, Department of Psychiatry
55 W 125th St, 13th floor, New York, NY 10029, USA

Research Interests

Neural, reinforcement learning and Bayesian models of healthy and aberrant behaviour in human and non-human animals, with a specific focus on compulsive behaviours such as substance use disorders, behavioural addictions, and obsessive-compulsive disorder. Model-based analysis of fMRI and neurophysiological data in healthy and clinical populations, with a specific focus on the neural dynamics of cortico-thalamo-striatal circuits.

Education

PhD in Psychobiology and Psychopharmacology, Sapienza – Università di Roma, IT, Jan 2012.
MSc by Res. in Philosophy, major Philosophy of Mind, University of Edinburgh, UK, Nov 2007.
Laurea in Philosophy, major Cognitive Science, Università degli Studi di Siena, IT, Nov 2005.

Academic Positions

March 2021 – present –Assistant Professor. Center for Computational Psychiatry. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
December 2019 – February 2021 – Instructor. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
September 2018 – November 2019 – Associate Scientist. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
January 2016 – August 2018 – Research Associate. School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA.
January 2013 – November 2015 – Research Associate. Wellcome Trust Centre for Neuroimaging, University College London, London, UK.
October 2007 – October 2012 – Internship (12 Months) and Early Stage Researcher (49 Months). Istituto di Scienze e Tecnologie della Cognizione, National Research Council, Rome, IT.

Present Grants

Start/end dates TBD. R01MH133625
Role: contact Principal Investigator. Title: “Neurocomputational mechanisms and connectivity dynamics underlying obsessive-compulsive disorder and phenotypical differentiations.”
01 Dec 2022 – 30 Nov 2024 – NIMH Exploratory/Developmental Research Grant. R21MH129898
Role: Principal Investigator (Berner LA, contact Principal Investigator). Title: “The computational role of corticostriatal circuits in binge-eating disorder symptoms and severity.”

Publications

Here is a complete list of my publications on PubMed and my page on Google Scholar

Perl O, Shuster A, Heflin M, Na S, Kidwai A, Booker N, Putnam WC, Fiore VG, Gu X. 2024. Nicotine-related beliefs induce dose-dependent responses in the human brain. Nat. Mental Health. doi: https://doi.org/10.1038/s44220-023-00188-9
Wilkinson CS, Luján MÁ, Hales C, Costa KM, Fiore VG, Knackstedt LA, Kober H. 2023. Listening to the Data: Computational Approaches to Addiction and Learning. J. Neurosci. 43 (45) 7547-7553; doi: https://doi.org/10.1523/JNEUROSCI.1415-23.2023
Kokorikou DS, Sarigiannidis I, Fiore VG, Parkin B, Hopkins A, El-Deredy W, Dilley L and Moutoussis M. 2023. Testing hypotheses about the harm that capitalism causes to the mind and brain: a theoretical framework for neuroscience research. Front. Sociol. 8:1030115. doi: https://doi.org/10.3389/fsoc.2023.1030115
Na S*, Rhoads SA*, Yu ANC, Fiore VG, Gu X. 2023. Towards a neurocomputational account of social controllability: From models to mental health. Neurosci Biobehav Rev. 20;148:105139. Doi: https://doi.org/10.1016/j.neubiorev.2023.105139.
Fiore VG, Smith AH, Figee M. 2023. Commentary: Toward Personalized Deep Brain Stimulation for Obsessive-Compulsive Disorder. Biol Psychiatry Cogn Neurosci Neuroimaging. 8(3): 235-237
Kato A, Shimomura K, Ognibene D, Parvaz MA, Berner LA, Morita K, Fiore VG. 2023. Computational models of behavioral addictions: state of the art and future directions. Addictive Behaviors. 140:107595. Doi: https://doi.org/10.1016/j.addbeh.2022.107595
Berner LA*, Fiore VG*, Chen J, Krueger A, Kaye WH, Viranda T, de Wit S. 2023. Impaired belief updating and devaluation in adult women with bulimia nervosa. Translational Psychiatry. Transl Psychiatry 13:2. Doi: https://doi.org/10.1038/s41398-022-02257-6
Kulkarni KR*, Schafer M*, Berner LA, Fiore VG, Heflin M, Hutchison K, Calhoun V, Filbey F, Pandey G, Schiller D, GuX. 2022. An interpretable and predictive connectivity-based neural signature for chronic cannabis use. Biol Psychiatry Cogn Neurosci Neuroimaging. 31:S2451-9022(22)00126-4. Doi: https://doi.org/doi.org/10.1016/j.bpsc.2022.04.009
Na S, Blackmore S, Chung D, O’Brien M, Banker S, Heflin M, Fiore VG, Gu X. 2022. Computational Mechanisms Underlying Illusion of Control in Delusional Individuals. Schizophrenia Research. 14:S0920-9964(22)00065-2. Doi: https://doi.org/10.1016/j.schres.2022.01.054.
Fiore VG, Gu X. 2022. Similar network compositions, but distinct neural dynamics underlying belief updating in environments with and without explicit outcomes. NeuroImage. 247:118821. doi: https://doi.org/10.1016/j.neuroimage.2021.118821.
Na S, Chung D, Hula A, Jung J, Fiore VG, Dayan P, Gu X. 2021. Humans Use Forward Thinking to Exert Social Control. eLife 10e64983. doi: https://doi.org/10.7554/eLife.64983
Shuster A, O’Brien M, Luo Y, Berner LA, Perl O, Heflin M, Kulkarni K, Chung D, Na S, Fiore VG, Gu X. 2021. Emotional adaptation during a crisis: decline in anxiety and depression after the initial weeks of COVID-19 in the United States. Transl. Psychiatry 11, 435. doi: https://doi.org/10.1038/s41398-021-01552-y
Fiore VG, De Felice N, Glicksberg BS, Perl O, Shuster A, Kulkarni K, O’Brien M, Pisauro MA, Chung D, Gu X. 2021. Containment of COVID-19: simulating the impact of different policies and testing capacities for contact tracing, testing, and isolation. PLoS One 16(3): e0247614. doi: https://doi.org/10.1371/journal.pone.0247614
Fiore VG, Guertler A-CV, Yu J-C, Tatineni CC, Gu X. 2021. A change of mind: globus pallidus activity and effective connectivity during changes in choice selections. Eur J Neurosci. 53: 2774– 2787. doi: https://doi.org/10.1111/ejn.15142
Yu J-C*, Fiore VG*, Briggs RW, Braud J, Rubia K, Adinoff B, Gu X. 2020. An insula‐driven network computes decision uncertainty and promotes abstinence in chronic cocaine users. Eur J Neurosci. 52: 4923– 4936. doi: https://doi.org/10.1111/ejn.14917
Ognibene D, Fiore VG, Gu X. 2019. Addiction beyond pharmacological effects: the role of environment complexity and bounded rationality. Neural Netw. 116:269-278 doi: 10.1016/j.neunet.2019.04.022
https://www.sciencedirect.com/science/article/pii/S0893608019301285
Fiore VG, Ognibene D, Adinoff B, Gu X. 2018. A Multilevel Computational Characterization of Endophenotypes in Addiction. ENeuro. 5(4).0151-18.2018; doi:10.1523/ENEURO.0151-18.2018
http://www.eneuro.org/content/5/4/ENEURO.0151-18.2018
Fiore VG, Nolte T, Rigoli F, Smittenaar P, Gu X, Dolan RJ. 2018. Value Encoding in the Globus Pallidus: fMRI reveals an interaction effect between reward and dopaminergic drive. NeuroImage. 173:249-257. doi:10.1016/j.neuroimage.2018.02.048
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929903/
Fiore VG, Kottler B, Gu X, Hirth F. 2017. In silico interrogation of insect central complex suggests computational roles for ellipsoid body in spatial navigation. Front Behav Neurosci doi: 10.3389/fnbeh.2017.00142
http://journal.frontiersin.org/article/10.3389/fnbeh.2017.00142/abstract
Fiore VG, Rigoli F, Stenner MP, Zaehle T, Hirth F, Heinze HJ, Dolan RJ. 2016. Changing pattern in the basal ganglia: motor switching under reduced dopaminergic drive. Sci. Rep. 6: 23327. doi: 10.1038/srep23327
http://www.nature.com/articles/srep23327
Hauser TU, Fiore VG, Moutoussis M, Dolan RJ. 2016. Computational psychiatry of ADHD: Neural gain impairments across Marrian levels of analysis . Trends Neurosci., doi: 10.1016/j.tins.2015.12.009
http://www.cell.com/trends/neurosciences/fulltext/S0166-2236(15)00283-0
Fiore VG, Dolan RJ, Strausfeld NJ, Hirth F. 2015. Evolutionary conserved mechanisms for the selection and maintenance of behavioural activity. Philosophical Transactions B. 370, 20150053 . DOI: 10.1098/rstb.2015.0053
http://rstb.royalsocietypublishing.org/content/370/1684/20150053
Fiore VG, Mannella F, Mirolli M, Latagliata EC, Valzania A, Cabib S, Dolan RJ, Puglisi-Allegra S, Baldassarre G. 2015. Corticolimbic catecholamines in stress: a computational model of the appraisal of controllability. Brain Structure and Function.220(3):1339-1353. Epub 2014 Feb 28 Doi: 10.1007/s00429-014-0727-7
http://link.springer.com/content/pdf/10.1007%2Fs00429-014-0727-7.pdf
Fiore VG, Sperati V, Mannella F, Mirolli M, Gurney K, Friston K, Dolan RJ, Baldassarre G. 2014. Keep focussing: striatal dopamine multiple functions resolved in a single mechanism tested in a simulated humanoid robot. Front. Psychol. 5:124. doi: 10.3389/fpsyg.2014.00124
http://journal.frontiersin.org/Journal/10.3389/fpsyg.2014.00124/abstract#sthash.lONLVv8C.dpuf
Taffoni F, Formica D, Schiavone G, Scorcia M, Tomassetti A, Polizzi di Sorrentino E, Sabbatini G, Truppa V, Mannella F, Fiore VG, et al. 2013. The “Mechatronic Board”: A Tool to Study Intrinsic Motivations in Humans, Monkeys, and Humanoid Robots. In G.Baldassarre and M.Mirolli (Eds.): Intrinsically Motivated Learning in Natural and Artificial Systems, Springer Berlin Heidelberg pages 411-432
Baldassarre G, Mannella F, Fiore VG, Redgrave P, Gurney K, Mirolli M. 2013. Intrinsically motivated action-outcome learning and goal-based action recall: a system-level bio-constrained computational model. Neural Netw. 41:168-187. doi: 10.1016/j.neunet.2012.09.015
Preprint in pdf – http://www.sciencedirect.com/science/article/pii/S0893608012002560
Fiore VG. 2010. Multiple realizations of the mental states – hunting for plausible chimeras. In M. D’Agostino et al. (Eds.): New Essays in Logic and Philosophy of Science, Kings College Publications: London, pages 529-538.
Preprint in pdf.
Fiore VG, Mannella F, Mirolli M, Gurney K, Baldassarre G. 2008. Instrumental Conditioning Driven by Neutral Stimuli: A Model Tested with a Simulated Robotic Rat. In M. Schlesinger et al. (Eds.), Proceedings of the 8th conference on Epigenetic Robotics, in University of Sussex, UK. Lund University Cognitive Studies, 139, pages 13-20.
Final version in pdf.

These authors contributed equally.

In Italian

Rizzoni, M. Calvano, R. et al. 2014. Libro Bianco – Università e Ricerca. Guidoni U, Fiore VG, et al. (Eds.) Rubbettino editore. ISBN 9788849841237

Teaching Experience

Ongoing

2022 – Present. Lecturer: “Neuro Core 3”. MSSM.
2022 – Present. Lecturer: “Fundamentals of Computational Psychiatry”. MSSM.
2018 – Present. Mentorship of PhD and graduate students, MSSM.

Past

Jul 2022 – “Bayesian Inference Tutorial”, for the Computational Psychiatry Summer Course.
Jul 2019 – “Introductory methods”, for the Computational Psychiatry Summer Course.
2017-18 – Temporary lecturer: “Introduction to Neuroscience” course, UTD.
2016 – 2018. Mentorship of PhD and undergraduate students, UTD.
2015 – Instructor: “Connectionism: structures to functions”, workshop for MSc students, UCL.
2012 – Temporary lecturer: “Computational embodied neuroscience” course, Sapienza – Univ. di Roma

Selected Conferences

Invited talk – Transcontinental Computational Psychiatry Workgroup (online only). April 2024
Mini symposium at the SfN Annual Meeting. Washington DC, US, October 2023
Invited talk – Transcontinental Computational Psychiatry Workgroup (online only). April 2021
Panel session – ACNP annual meeting. Orlando, US, December 2019 .
OHBM annual meeting. Rome, IT, June 2019
FENS forum of Neuroscience 2018. Berlin, DE, July 2018
SfN, Annual Meeting of the Society for Neuroscience. Washington DC, US, November 2017.
IBAGS, 12th International Basal Ganglia Society Meeting. Mérida, MX, March 2017
Genetics Society Autumn Meeting, Building the brain: from genes, to circuits and cognition. London, UK, November 2015
FENS, Brain Conference – Bridging Neural Mechanisms and Cognition. Rungstedgaard, DK, April 2015

Ad hoc reviewer

Addiction Neuroscience; Addictive Behaviors; Basal Ganglia; Brain Research; Cerebral Cortex; Cognitive, Affective, & Behavioral Neuroscience; Computational Psychiatry; Drug and Alcohol Dependence; Frontiers in Neuroscience; Frontiers in Psychology; Journal of Neuroscience; Nature Communications; Neural Networks; NeuroImage; Psychological Medicine; Psychological Science; Scientific Reports